What is the initial amiodarone dose for adult cardiac arrest?

What is the initial amiodarone dose for adult cardiac arrest?

• A. 300 mg IV/IO
• B. 150 mg IV/IO
• C. 450 mg IV/IO
• D. 600 mg IV/IO

Answer: (A)

In adult cardiac arrest with a shockable rhythm, amiodarone is given as a rapid IV/IO bolus after defibrillation attempts. The initial dose is 300 mg to quickly achieve effective levels in the heart and increase the chance of converting the rhythm. If the rhythm remains pulseless after subsequent shocks, a second bolus of 150 mg is given, for a total of 450 mg during that arrest. This approach balances the need for rapid antiarrhythmic effect with guideline-recommended dosing. A smaller initial dose would be less effective, while larger initial doses are not standard practice.

In adult cardiac arrest with a shockable rhythm, amiodarone is given as a rapid IV/IO bolus after defibrillation attempts. The initial dose is 300 mg to quickly achieve effective levels in the heart and increase the chance of converting the rhythm. If the rhythm remains pulseless after subsequent shocks, a second bolus of 150 mg is given, for a total of 450 mg during that arrest. This approach balances the need for rapid antiarrhythmic effect with guideline-recommended dosing. A smaller initial dose would be less effective, while larger initial doses are not standard practice.