What is our dose and route for TXA?

What is our dose and route for TXA?

• A. 2 g TXA IV/IO in 200 mL D5W over 15 minutes
• B. 0.5 g TXA IV/IO in 50 mL NS over 5 minutes
• C. 1 g TXA IV/IO in 100 mL D5W or NS over 10 minutes
• D. 1 g TXA IV/IO in 100 mL D5W or NS over 30 minutes

Answer: (C)

TXA is given to rapidly counteract fibrinolysis in traumatic bleeding, so it should be delivered as a single, early dose that reaches effective levels quickly. The standard prehospital dosing is 1 gram given IV or IO, diluted in 100 mL of D5W or normal saline, infused over about 10 minutes. This provides a controlled, rapid infusion that achieves therapeutic blood concentrations without an excessive fluid load. Other options are not correct because they either use a higher or lower dose or extend the infusion time beyond 10 minutes, which delays achieving the needed plasma levels.

TXA is given to rapidly counteract fibrinolysis in traumatic bleeding, so it should be delivered as a single, early dose that reaches effective levels quickly. The standard prehospital dosing is 1 gram given IV or IO, diluted in 100 mL of D5W or normal saline, infused over about 10 minutes. This provides a controlled, rapid infusion that achieves therapeutic blood concentrations without an excessive fluid load.

Other options are not correct because they either use a higher or lower dose or extend the infusion time beyond 10 minutes, which delays achieving the needed plasma levels.